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For example, exposure to an enriched environment promotes the maturation of newborn neurons in adult hippocampus (Zhao et al., 2008) and strongly induces Dnmt1 mRNA in the mouse cortex (Rampon et al., 2000)

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Milk thistle may also interact with the following medications, though the interactions are less concerning and only require monitoring after ingestion:2 Fosphenytoin-phenytoin Indinavir Losartan Metronidazole Sirolimus Tolbutamide Vitamin K antagonists On the brighter side, most adverse reactions to milk thistle are minor and brief

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